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    1. Developmental Biology

    Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers

    Nanoka Suzuki et al.
    Arid3a, a component of H3K9 me3 demethylases, regulates regeneration of the proximal nephric tubule through the evolutionarily conserved regeneration signal-response enhancer.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

    Stanley Nithianantham et al.
    TOG (tumor overexpressed gene) domains organize then polymerize tubulins at microtubule plus ends.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae

    Xinbo Wang et al.
    Immunoisolation combined with quantitative proteomics identifies 79 proteins enriched in the tubular endoplasmic reticulum and provides useful tool for analyzing this organelle's functions.
    1. Cell Biology
    2. Neuroscience

    VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo

    Alyssa E Johnson et al.
    The AAA-ATPase VCP sustains sarcoplasmic proteostasis, in part, by controlling autophagosome-lysosome fusion and the integrity of a dynamic tubular lysosomal network.
    1. Cancer Biology
    2. Genetics and Genomics

    Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

    Iris E Glykofridis et al.
    Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation

    Axel F Brilot et al.
    Cryo-EM structures reveal that the conserved CM1 motif drives γTuRC assembly by bridging adjacent γTuSC.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

    Pelin Ayaz et al.
    Using linked TOG domains that each bind a curved conformation of αβ-tubulin, a microtubule polymerase catalyzes fast elongation by concentrating αβ-tubulin near the polymer end.
    1. Cell Biology

    Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

    Songyu Wang et al.
    Experiments with mammalian cells and Xenopus egg extracts elucidate how three proteins cooperate to shape the reticular endoplasmic reticulum network.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

    Paolo Grumati et al.
    Full length RTN3 homodimerization mediates ER tubules fragmentation and their subsequent delivery to lysosome.
    1. Structural Biology and Molecular Biophysics

    The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

    Ahmad Abdelzaher Zaki Khalifa et al.
    A structure of the ciliary inner junction at 3.6 Å resolution permits atomic modeling of six inner junction proteins and their interactions with acetylated lysine 40 loops of alpha tubulins.