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    1. Cancer Biology
    2. Medicine

    Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

    S Jordan Kerns et al.
    Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.
    1. Cancer Biology

    Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

    Chun-Chun Cheng et al.
    The cancer testis antigen COX6B2 enhances cytochrome c oxidase activity thereby promoting proliferation and survival in cancer cells and represents a therapeutic target for inhibiting oxidative phosphorylation selectively in tumors.
    1. Genetics and Genomics

    HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

    Jessica SY Ho et al.
    HNRNPM regulates exon inclusion and circularization events on transcripts of key homeostatic genes promoting cancer growth.
    1. Cancer Biology

    The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

    Zane A Gibbs et al.
    Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The discriminatory power of the T cell receptor

    Johannes Pettmann et al.
    The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.
    1. Cancer Biology
    2. Computational and Systems Biology

    Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

    Jia-Ren Lin et al.
    t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

    Lian He et al.
    A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.
    1. Immunology and Inflammation

    Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

    Cécile Alanio et al.
    Naïve CD8+ T cells are dysregulated during chronic hepatitis C (HCV) infection, and this is reversible after viral clearance.
    1. Cancer Biology

    Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

    Romi Gupta et al.
    The protein IFI6 regulates DNA replication via the transcription factor E2F2, which is necessary for transformation and growth of melanomas induced by the NRASQ61K mutant oncogene product.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

    Gerald Willimsky et al.
    Analysis of neo-splicetope-specific T cell responses strongly questions the idea that in vitro proteasome-catalyzed peptide splicing reaction simulates the in vivo situation with the same high fidelity as the in vitro generation of non-spliced epitopes.