Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.

In contrast with earlier conclusions, negative selection has a major role in cancer evolution.

Evolution of tumor suppressor genes can involve a trade-off because the acquisition of certain anti-cancer characteristics diminishes the ability to regenerate damaged tissue.

A general framework captures the evolutionary routes leading to the formation and progression of tumors.

t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.

Analyses of genetically engineered mouse models reveal the androgen receptor-independent properties of a luminal stem/progenitor cell in the prostate epithelium, and its ability to serve as a cell of origin for castration-resistant prostate cancer.

Combined cell labelling with a bi-cistronic reporter-gene vector and gold nanorods enables short- and long-term cell tracking in vivo via multimodal imaging (multispectral optoacoustic tomography, bioluminescence, fluorescence) with high spatial resolution.

Genetics of a canine transmissible tumour show how the world’s oldest cancer “metastasised” through the global dog population – and captured, maintained and rearranged its mitochondrial DNA along the way.

Midbrain dopaminergic neurons and a cortex-like structure called the arcopallium form part of a circuit that enables young songbirds to compare their own song with a template stored in memory, and use any discrepancies to improve their performance.

Mutations in the DNA of ovarian cyst fluid can inform the need for surgery and indicate the type of neoplastic lesion present.