116 results found
    1. Cell Biology
    2. Human Biology and Medicine

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao et al.
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Cancer Biology
    2. Immunology and Inflammation

    Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy

    Shuhong Qi et al.
    Tregs form an "immunosuppressive ring" around solid tumors that is broken down during adoptive cell therapy and cyclophosphamide combination immunotherapy.
    1. Cancer Biology
    2. Computational and Systems Biology

    Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

    Julien Racle et al.
    A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

    Thornton W Thompson et al.
    Macrophages respond to elevated levels of CSF-1 in tumor micro-environments by expressing a ligand for the NKG2D immunoreceptor.
    1. Cell Biology
    2. Human Biology and Medicine

    Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

    Alexandra Naba et al.
    Many extracellular matrix proteins that are up-regulated during breast tumor progression enhance metastasis, and some are prognostic indicators of poor survival.
    1. Cancer Biology
    2. Cell Biology

    Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties

    Delphine Fessart et al.
    Epithelial tumors secrete the ER-resident AGR2 in the extracellular matrix to function as a novel essential microenvironmental regulator of epithelial tissue architecture, which leads to tumorigenicity.
    1. Neuroscience

    Environmental stimuli shape microglial plasticity in glioma

    Stefano Garofalo et al.
    The microenvironment of brain tumors can be modulated by in vivo conditions that change the brain levels of BDNF and IL-15, with effects on innate immune cell activation.
    1. Cell Biology
    2. Human Biology and Medicine

    Cancer Metabolism: Partners in the Warburg effect

    Joshua D Rabinowitz, Hilary A Coller
    Insight
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    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

    Kelda Chia et al.
    Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.

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