235 results found
    1. Cancer Biology

    Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

    Christine Mantis et al.
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Cancer Biology

    Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

    Shiran Ferber et al.
    Treatment with precision nanomedicine in combination with an anti-angiogenic peptide enhance anti-tumor efficacy while minimizing toxicities in a pre-clinical glioblastoma model, making this approach a promising and important therapeutic alternative for patients.
    1. Cell Biology

    The cell proliferation antigen Ki-67 organises heterochromatin

    Michal Sobecki et al.
    Antigen Ki-67, which is widely used as a cell proliferation marker, controls heterochromatin organisation and gene expression.
    1. Plant Biology

    A fungal member of the Arabidopsis thaliana phyllosphere antagonizes Albugo laibachii via a GH25 lysozyme

    Katharina Eitzen et al.
    A basidiomycete yeast closely related to fungal smuts is an antagonistic microbe in the Arabidopsis leaf phyllosphere that inhibits infection by Albugo laibachii via a GH25 hydrolase with lysozyme activity.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

    Lisa Landskron et al.
    Genetic analyses uncovered that the asymmetrically long non-coding RNA cherub is required for brain tumor growth.
    1. Cancer Biology

    Cancer Immunotherapy: A peptide puzzle

    Jian Guan, Nilabh Shastri
    Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Making sense of replications

    Brian A Nosek, Timothy M Errington
    The first results from the Reproducibility Project: Cancer Biology suggest that there is scope for improving reproducibility in pre-clinical cancer research.

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