423 results found
    1. Cancer Biology

    Cancer Immunotherapy: A peptide puzzle

    Jian Guan, Nilabh Shastri
    Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
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    1. Cancer Biology

    Rejection of immunogenic tumor clones is limited by clonal fraction

    Ron S Gejman et al.
    A new, high-throughput in vivo MHC-I peptide minigene library platform shows that the naive immune system cannot eliminate cells presenting immunogenic antigens found at low frequencies within a growing tumor.
  1. Point of View: Unbridle biomedical research from the laboratory cage

    Garet P Lahvis
    Recent advances in technology now make it possible to carry out biomedical research on animals living in the wild, or captive animals living in naturalistic conditions.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Evolutionary Biology
    Mouse illustration

    The Natural History of Model Organisms: Insights into mammalian biology from the wild house mouse Mus musculus

    Megan Phifer-Rixey, Michael W Nachman
    Studies of the house mouse Mus musculus have provided important insights into mammalian biology, and efforts to study wild house mice and to create new inbred strains from wild populations have the potential to increase its usefulness as a model system.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Cancer Biology
    2. Cell Biology

    Genetic Diversity: Driving cancer evolution

    Devon M Fitzgerald, Susan M Rosenberg
    Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.
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    1. Cell Biology
    2. Immunology and Inflammation

    Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

    Maria-Bernadette Madel et al.
    Osteoclasts emerging in inflammation are heterogeneous and encompass a strongly inflammatory subset with a high resorbing activity and an immune suppressive subset that are able to control each other.
    1. Cell Biology

    ERK3/MAPK6 controls IL-8 production and chemotaxis

    Katarzyna Bogucka et al.
    Understudied atypical MAPK, ERK3 controls epithelial secretome and chemotaxis.
    1. Cancer Biology
    2. Immunology and Inflammation

    Preclinical murine tumor models: a structural and functional perspective

    Marion V Guerin et al.
    Dissecting structural, cellular and molecular differences between transplanted and spontaneous mouse tumor models, highlighting their relevance for predicting the efficacy of anti-cancer treatments in patients.

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