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66 results found
    1. Cancer Biology
    2. Physics of Living Systems

    Collective forces of tumor spheroids in three-dimensional biopolymer networks

    Christoph Mark et al.
    The forces that multicellular tumor aggregates exert on their environment lead to non-linear, scale-invariant tissue deformations far away from the tumor, which can be exploited to quantify its collective contractility.
    1. Computational and Systems Biology
    2. Neuroscience

    3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images

    Chentao Wen et al.
    A deep learning-based pipeline was developed for extracting cellular signals flexibly from moving cells in 3D time lapse images, and it outperformed previous methods under different imaging conditions.
    1. Cancer Biology

    Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

    Patricia L Theard et al.
    Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.
    1. Cancer Biology

    Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

    Anthony Essex et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    1. Cancer Biology

    Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

    Shiran Ferber et al.
    Treatment with precision nanomedicine in combination with an anti-angiogenic peptide enhance anti-tumor efficacy while minimizing toxicities in a pre-clinical glioblastoma model, making this approach a promising and important therapeutic alternative for patients.
    1. Cancer Biology
    2. Cell Biology

    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

    Yen-Lin Huang et al.
    Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.
    1. Cell Biology
    2. Developmental Biology

    CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

    Myo-Hyeon Park et al.
    Cyr61 autoregulating tip cell activity by interlinking integrin and Hippo pathway and targeting Cyr61 provides promising therapeutic approach for the treatment of pathological angiogenesis, including tumour angiogenesis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

    Jianneng Li et al.
    Prostate cancer resistance to androgen receptor antagonist therapy occurs by way of tumors impeding local glucocorticoid metabolism and inactivation and thereby permitting sustained glucocorticoids to stimulate up-regulated glucocorticoid receptor.
    1. Physics of Living Systems

    Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

    Monika E Dolega et al.
    Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.

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