203 results found
    1. Cancer Biology

    Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

    Ana Rita Pombo Antunes et al.
    The heterogeneity of immune cell types in glioblastoma tumors depends on the tumor's genetic make-up and treatment status and is an incompletely mined source of novel therapeutic targets.
    1. Cell Biology

    Tetherin is an exosomal tether

    James R Edgar et al.
    Blocking acidification causes endosomes to fuse with the plasma membrane, releasing exosomes that remain attached to the cell surface via the anti-viral protein tetherin.
    1. Cancer Biology
    2. Immunology and Inflammation

    Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy

    Shuhong Qi et al.
    Tregs form an "immunosuppressive ring" around solid tumors that is broken down during adoptive cell therapy and cyclophosphamide combination immunotherapy.
    1. Neuroscience

    Large and fast human pyramidal neurons associate with intelligence

    Natalia A Goriounova et al.
    Neurons from individuals with higher IQ scores have larger dendrites, are able to maintain faster action potentials, and thus process information more efficiently.
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Immunology and Inflammation

    Functionally diverse human T cells recognize non-microbial antigens presented by MR1

    Marco Lepore et al.
    MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule, MR1.
    1. Immunology and Inflammation

    High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

    Antoine Marçais et al.
    Chronic engagement of Natural killer cell inhibitory receptors by MHC-I molecules maintains a high activity of the mTOR pathway allowing subsequent amplification of signaling through activating receptors upon acute stimulation.
    1. Cancer Biology

    Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

    Yaqing Zhang et al.
    In the pancreas, reciprocal interactions between epithelial cells and myeloid cells determine the balance between tissue repair and carcinogenesis by regulating acinar cell plasticity through differential activation of EGFR/MAPK signaling.
    1. Neuroscience

    Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

    Achira Roy et al.
    Acute one-hour treatment of Pik3ca mutant mice with a novel anti-epilepsy drug suppresses seizures despite continued developmental brain dysmorphology, promising a new therapeutic strategy for patients with intractable pediatric epilepsy.

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