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    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind et al.
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Cancer Biology

    T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

    Marta Canel et al.
    Cancer cell expression of the T-cell co-stimulatory molecule CD80, or treatment with agonistic antibodies targeting the T-cell co-stimulatory receptors OX-40 or 4-1BB, enhances the anti-tumor activity of FAK inhibition.
    1. Cancer Biology

    The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

    Gui-Zhen Wang et al.
    The chemokine CXCL13 is critical to the development of air pollution- and tobacco smoke-induced lung cancers.
    1. Cancer Biology

    Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone

    Wing Yin Cheng et al.
    The PPARγ protein acts in macrophages to inhibit breast cancer progression and mediate the anti-tumor effects of rosiglitazone by suppressing Gpr132 – a pro-tumor and pro-inflammatory factor in macrophages.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Cancer Biology
    2. Computational and Systems Biology

    Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

    Julien Racle et al.
    A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.
    1. Cancer Biology

    Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

    Yaqing Zhang et al.
    In the pancreas, reciprocal interactions between epithelial cells and myeloid cells determine the balance between tissue repair and carcinogenesis by regulating acinar cell plasticity through differential activation of EGFR/MAPK signaling.
    1. Cancer Biology

    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

    Alba Nicolas-Boluda et al.
    Tumor stiffness blocks T cell migration in tumors.
    1. Developmental Biology
    2. Immunology and Inflammation

    Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice

    Ying Wang et al.
    A distinct resident macrophage subpopulation that localizes to the adipose stroma and fibrous capsule of the nulliparous mammary gland and to extracellular matrix-enriched stroma surrounding mammary tumors is identified.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

    Lili Liao et al.
    Major secondary tumor suppressors in kidney cancer are required to maintain the activity of a tumor suppressive transcription factor after the loss of the primary tumor suppressor VHL.