351 results found
    1. Developmental Biology
    2. Human Biology and Medicine

    MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

    Kent Riemondy et al.
    Inhibition of microRNA-203 by oncogenic HRas mutations promotes skin cancer initiation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

    Kelda Chia et al.
    Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.
    1. Cancer Biology

    NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

    Zhi-Jie Xiao et al.
    NFATc2 maintains the drug-induced TIC phenotypes through trans-activating SOX2/ALDH1A1 expression and scavenging stress from ROS.
    1. Cancer Biology
    2. Developmental Biology

    Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

    Erin A Bassett et al.
    The earliest steps of tumor initiation in the cerebellum are regulated by critical interactions between pre-tumor cells and stromal cells, which can be manipulated by targeting the Norrin/Frizzled4 signaling axis.
    1. Cell Biology
    2. Human Biology and Medicine

    Defective apical extrusion signaling contributes to aggressive tumor hallmarks

    Yapeng Gu et al.
    Disrupting extrusion, a process that drives epithelial cell death, leads to increased cell survival, poor barrier function, and enhanced cell invasion and, thereby, promotes tumor initiation and progression.
    1. Immunology and Inflammation

    Cancer: How the immune system spots tumors

    Yasutaka Okabe, Ruslan Medzhitov
    Insight
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    1. Cell Biology
    2. Human Biology and Medicine

    Prostate Cancer: SPOP the mutation

    Leah Rider, Scott D Cramer
    Insight
    Available as:
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Computational and Systems Biology

    Research: Bias in the reporting of sex and age in biomedical research on mouse models

    Oscar Flórez-Vargas et al.
    A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.
    1. Human Biology and Medicine

    Science Forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research

    Nicholas GD Masca et al.
    The RIPOSTE framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies.

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