Increased expression of Drosophila Tailless (TLX homologue) reverts intermediate progenitors to neural stem cells, inducing tumourigenesis via Asense repression and reflecting mutually exclusive TLX and ASCL1 expression in human glioblastoma.
Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.
Overexpression of BAG2—a novel mutant p53 binding protein—in tumors inhibits MDM2-mediated mutant p53 degradation, which leads to the accumulation of mutant p53 protein and promotes tumorigenesis.
A newly discovered feedback amplification loop between stem cells and their immediate daughter progenitor cells drives epithelial regeneration and tumor development.
The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.
An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.
Dual FAK/PYK2 kinase inhibition disrupts GSK3β phosphorylation and may present a new treatment for colorectal cancer in patients carrying APC mutations.
ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.
