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TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2
Amy T Ku et al.
Overexpression of TCF7L1 overrides oncogenic Ras-induced senescence, induces cell migration, and promotes growth of skin squamous cell carcinoma independently of its interaction with β-catenin.
SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer
Ziling Fang et al.
SPIN1, a nucleolar protein, plays an oncogenic role by suppressing the tumor suppressor p53's function via regulation of the uL18-MDM2-p53 pathway.
Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation
Kai Fu et al.
The nuclear protein Sam68 plays a role in the genotoxic stress-initiated "nuclear to cytoplasmic" activation of NF-κB and is involved in the development and survival of colon cancer.
Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in
Susumu Hirabayashi, Ross L Cagan
The ability of tumors to respond to nutritional signals is mediated by Salt-inducible kinases, which ensure tumor growth under nutrient-rich conditions including obesity.
Stem Cells and Regenerative Medicine
The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells
Lisa Landskron et al.
Genetic analyses uncovered that the asymmetrically long non-coding RNA cherub is required for brain tumor growth.
A role for PVRL4-driven cell–cell interactions in tumorigenesis
Natalya N Pavlova et al.
A protein called PVRL4 has a central role in a number of cancers that originate in epithelial tissue, and anti-PVRL4 antibodies could be used to treat some of these cancers.
Daam2 driven degradation of VHL promotes gliomagenesis
Wenyi Zhu et al.
The glial developmental factor, Daam2, promotes glioma tumorigenesis by degrading the VHL tumor suppressor, illustrating how dysregulation of gliogenic factors can impact tumor suppressor activity and promote glioma tumorigenesis.
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
Lorenzo Rinaldi et al.
Dnmt3a and Dnmt3b are dispensable for epidermal homeostasis but act as potent tumor suppressors regarding skin squamous tumorigenesis.
Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis
Peng Liao et al.
Palmitoylation recruits the phosphatase SCP1 to endothelial cell membranes where it negatively regulates Akt kinase activity, resulting in suppressed angiogenesis and decreased tumorigenesis.
Protein phase separation and its role in tumorigenesis
Shan Jiang et al.
The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
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