949 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

    Julien Racle et al.
    A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.
    1. Genomics and Evolutionary Biology
    2. Human Biology and Medicine

    Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia

    Jiguang Wang et al.
    A general framework captures the evolutionary routes leading to the formation and progression of tumors.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

    Katarzyna Nowak et al.
    Nutrient limitation elicits differential responses in cells lacking the tumor suppressor PTEN and in normal cells, resulting in hyperplastic overgrowth of PTEN mutant tissue independent of additional mutations.
    1. Cell Biology
    2. Human Biology and Medicine

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao et al.
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Cell Biology
    2. Human Biology and Medicine

    Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

    Seung-Hyun Ro et al.
    Sestrin2 loss could be a universal mechanism of human colon carcinogenesis that allows for barrier dysfunction, mTORC1 hyperactivation, unrestricted tumor growth and chemoresistance.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium

    Joaquim Grego-Bessa et al.
    In addition to its role in regulating proliferation and cell death, the PTEN tumor suppressor regulates epithelial morphogenesis through the PDK1 kinase.
    1. Cell Biology

    EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

    Itziar Pinilla-Macua et al.
    A small pool of active epidermal growth factor (EGF) receptors, which are capable of ubiquitylation and efficient endocytosis in vivo, is sufficient to support EGF-receptor-dependent tumor growth by signaling primarily through the Ras-MAPK pathway.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

    Anil M Narasimha et al.
    The retinoblastoma tumor suppressor regulates cell cycle progression when it's in 14 mono-phosphorylated isoforms.
    1. Cancer Biology
    2. Cell Biology

    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

    Jean M Mulcahy Levy et al.
    Pre-clinical and patient data show that inhibition of autophagy with an approved, inexpensive, well-tolerated drug can overcome resistance to BRAFV600E inhibition in multiple brain tumor subtypes with different resistance mechanisms.
    1. Cell Biology
    2. Human Biology and Medicine

    Defective apical extrusion signaling contributes to aggressive tumor hallmarks

    Yapeng Gu et al.
    Disrupting extrusion, a process that drives epithelial cell death, leads to increased cell survival, poor barrier function, and enhanced cell invasion and, thereby, promotes tumor initiation and progression.

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