182 results found
    1. Cancer Biology
    2. Cell Biology

    Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

    Stephin J Vervoort et al.
    Global transcriptome analysis reveals that the transcription factor SOX4 can promote breast tumor development via tumor angiogenesis by promoting paracrine signalling through endothelin-1.
    1. Cancer Biology
    2. Cell Biology

    Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis

    Peng Liao et al.
    Palmitoylation recruits the phosphatase SCP1 to endothelial cell membranes where it negatively regulates Akt kinase activity, resulting in suppressed angiogenesis and decreased tumorigenesis.
    1. Cancer Biology

    MPDZ promotes DLL4-induced Notch signaling during angiogenesis

    Fabian Tetzlaff et al.
    The multiple PDZ domain protein recruits Notch ligands to Nectin-2, which increases Notch signaling activity during angiogenesis.
    1. Cell Biology
    2. Developmental Biology

    CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

    Myo-Hyeon Park et al.
    Cyr61 autoregulating tip cell activity by interlinking integrin and Hippo pathway and targeting Cyr61 provides promising therapeutic approach for the treatment of pathological angiogenesis, including tumour angiogenesis.
    1. Cancer Biology
    2. Cell Biology

    A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

    Francesca Angiolini et al.
    Endothelial cells express a soluble isoform of the L1CAM cell adhesion molecule that is generated by the splicing factor NOVA2 and induces angiogenesis, with relevant implications for ovarian cancer vascularization.
    1. Neuroscience

    Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

    Michael O Breckwoldt et al.
    Correlated magnetic resonance imaging and ultramicroscopy resolves macro- and microvasculature in glioma models and allows treatment monitoring of antiangiogenic therapy.
    1. Developmental Biology

    Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

    Maria V Gelfand et al.
    Interactions between Neuropilin-1 and VEGFR2, rather than VEGF-Neuropilin-1 binding, underlie Neuropilin-1's critical function in VEGF-mediated vascular development.
    1. Cancer Biology
    2. Cell Biology

    Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

    Giulia Fianco et al.
    Retention of Caspase-8 confers a selective advantage to glioblastoma and represents a novel therapeutic target.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

    Jeroen Overman et al.
    A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions is reported.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

    Fransky Hantelys et al.
    In mouse cardiomyocytes, (lymph)angiogenic growth factors are induced during early hypoxia by a translational mechanism involving a new IRES trans-acting factor, vasohibin-1.

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