3,458 results found
    1. Chromosomes and Gene Expression

    The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

    Yuan Zhang, Yang Xie ... David J Mangelsdorf
    Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.
  1. Living Science: A good life

    Eve Marder
    Following a career in science involves long hours and hard work, but as Eve Marder explains in the first of a series of columns, it can also be extremely rewarding.
    1. Neuroscience

    Neuroscience: How keeping active pays off in the olfactory system

    Kevin Monahan, Stavros Lomvardas
    Version of Record
    Insight
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions

    Matthew P Miller, Elçin Ünal ... Angelika Amon
    Preventing premature interactions between microtubules and protein-based structures called kinetochores ensures that chromosomes are segregated by meiosis rather than mitosis in reproductive cells.
    1. Developmental Biology
    2. Neuroscience

    Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling

    Hao Wu, John Williams, Jeremy Nathans
    The first survey of the complete morphologies of nerve endings in the skin of mice has revealed enormous structural diversity.
    1. Biochemistry and Chemical Biology

    Cancer: How does doxorubicin work?

    Anand G Patel, Scott H Kaufmann
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

    Bray Denard, Ching Lee, Jin Ye
    Cleavage of a membrane-bound transcription factor by the chemotherapeutic reagent doxorubicin can block the proliferation of tumor cells.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak, David S Greenberg ... Jason ND Kerr
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.

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