119 results found
    1. Developmental Biology

    An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

    Florian Razy-Krajka et al.
    A gene network for heart versus head muscle specification has been identified in the tunicate Ciona.
    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Developmental Biology
    2. Evolutionary Biology

    Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians

    Alberto Stolfi et al.
    Embryos of distantly related sea squirt species are nearly identical but develop according to different gene regulatory mechanisms.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome sequence of the colonial chordate, Botryllus schlosseri

    Ayelet Voskoboynik et al.
    The Botryllus schlosseri genome yields insights into the evolution of hematopoiesis.
    1. Ecology
    2. Biochemistry and Chemical Biology

    Biochemistry: Shedding light on sunscreen biosynthesis in zebrafish

    Carolyn A Brotherton, Emily P Balskus
    Insight
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    1. Neuroscience

    Developmental Neuroscience: Catching a wave

    P Michelle Fogerson, John R Huguenard
    Insight
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    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Science Forum: Considerations when investigating lncRNA function in vivo

    Andrew R Bassett et al.
    We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

    Victor Ovchinnikov et al.
    Computer simulations of the evolution of broadly neutralizing antibodies against HIV suggest that non-traditional pathways involving framework mutations which lead initially to increased antibody flexibility do occur, but can be avoided by appropriate vaccine design.
    1. Developmental Biology

    Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm

    Raphaël Aguillon et al.
    Several neuronal subtypes found in the early zebrafish olfactory placode are not derived from the neural crest, as previously thought, but from the preplacodal ectoderm.
    1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi et al.
    ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.

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