9 results found
    1. Microbiology and Infectious Disease
    2. Neuroscience

    The sheddase ADAM10 is a potent modulator of prion disease

    Hermann C Altmeppen et al.
    A lack of ADAM10-mediated shedding increases prion protein levels at the plasma membrane and promotes the generation of pathological prion proteins, which accelerates prion disease in mice.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Trogocytosis-associated cell to cell spread of intracellular bacterial pathogens

    Shaun Steele et al.
    Live intracellular bacterial pathogens can transfer from infected cells to uninfected macrophages upon cell-to-cell contact.
    1. Neuroscience

    Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

    Hadeel Alyenbaawi et al.
    A traumatic brain injury model is invented for larval zebrafish and applied to a new fluorescent 'tauopathy reporter fish', revealing a role for seizures in progression towards dementias.
    1. Cell Biology
    2. Neuroscience

    Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

    Kirby M Donnelly et al.
    Prion-like transfer of mutant huntingtin aggregates from presynaptic to postsynaptic neurons is enhanced by neuronal silencing and requires passage through the cytoplasm of Draper-expressing phagocytic glia in adult Drosophila brains.
    1. Cancer Biology

    Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

    Lan-Feng Dong et al.
    A genetic approach documents that mitochondrial DNA moves from donor cells to recipient mtDNA-depleted cells in whole mitochondria and that this restores mitochondrial respiration and the capacity of the cells to form tumours.
    1. Developmental Biology

    Muscle niche-driven Insulin-Notch-Myc cascade reactivates dormant Adult Muscle Precursors in Drosophila

    Rajaguru Aradhya et al.
    Adult muscle precursors (AMP) cells in Drosophila send out filopodia to interact with neighbouring muscles, which drive the reactivation of AMPs via an Insulin-Notch-Myc cascade.
    1. Cell Biology
    2. Developmental Biology

    Physical association between a novel plasma-membrane structure and centrosome orients cell division

    Takefumi Negishi et al.
    A newly discovered membrane structure associates with one of the centrioles and affects two important centrosomal events in epidermal cells – ciliary positioning and spindle orientation – through a physical interaction.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation

    Javier Periz et al.
    In contrast to current knowledge that predicts that apicomplexan actin is unconventional, use of Chromobodies demonstrate that Toxoplasma F-actin forms a long, stable, highly dynamic tubular network that is required for material transfer and parasite maturation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

    Maeva Dupont et al.
    Type-I interferon enriched microenvironment generated by Mycobacterium tuberculosis induces the Siglec-1 receptor expression in human macrophages, including on tunneling nanotubes, and contributes to the exacerbation of cell-to-cell transfer of HIV-1.

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