16 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

    Maeva Dupont, Shanti Souriant ... Geanncarlo Lugo-Villarino
    Type-I interferon enriched microenvironment generated by Mycobacterium tuberculosis induces the Siglec-1 receptor expression in human macrophages, including on tunneling nanotubes, and contributes to the exacerbation of cell-to-cell transfer of HIV-1.
    1. Cancer Biology
    2. Cell Biology

    Treatment with tumor-treating fields (TTFields) suppresses intercellular tunneling nanotube formation in vitro and upregulates immuno-oncologic biomarkers in vivo in malignant mesothelioma

    Akshat Sarkari, Sophie Korenfeld ... Emil Lou
    Cancer-directed treatment using Tumor-Treating Fields spatially modulates the tumor microenvironment at the cellular and molecular levels, decreasing nanotube-based cellular networks of communication while creating a microenvironment more susceptible to immunotherapeutic strategies.
    1. Cell Biology

    Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

    Roberto Notario Manzano, Thibault Chaze ... Christel Brou
    Proteomic analysis of tunneling nanotubes (TNTs) identifies CD9 and CD81 as major positive regulators of TNT formation.
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Cell Biology
    2. Physics of Living Systems

    Zebrafish airinemes optimize their shape between ballistic and diffusive search

    Sohyeon Park, Hyunjoong Kim ... Jun Allard
    Mathematical characterization of the shape of cellular protrusions that form cell–cell contacts in tissues reveals the parameters required for optimizing biological functional objectives, like maximizing cell–cell contact and communicating directional information.
    1. Cell Biology

    Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein

    Congyan Zhang, Randy Schekman
    A human endogenous fusogen, syncytin, which facilitates placental cell-cell fusion during early embryonic development, mediates the formation of open-ended membrane tubular connections between other cell types that efficiently promotes the intercellular transfer of cytoplasmic cargos including Cas9 protein and organelles.
    1. Cell Biology
    2. Physics of Living Systems

    Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

    Camille Morel, Eline Lemerle ... Emmanuel Lemichez
    Caveolin-1 controls the width of transendothelial cell tunnels via a direct or indirect effect on membrane bending rigidity.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Filopodia powered by class x myosin promote fusion of mammalian myoblasts

    David W Hammers, Cora C Hart ... H Lee Sweeney
    Filopodia driven by class X myosin promote the fusion of mammalian myoblasts in the development of skeletal muscle and are important for the regeneration of skeletal muscle following muscle injury.
    1. Developmental Biology

    Muscle niche-driven Insulin-Notch-Myc cascade reactivates dormant Adult Muscle Precursors in Drosophila

    Rajaguru Aradhya, Monika Zmojdzian ... Krzysztof Jagla
    Adult muscle precursors (AMP) cells in Drosophila send out filopodia to interact with neighbouring muscles, which drive the reactivation of AMPs via an Insulin-Notch-Myc cascade.
    1. Cell Biology
    2. Developmental Biology

    Physical association between a novel plasma-membrane structure and centrosome orients cell division

    Takefumi Negishi, Naoyuki Miyazaki ... Naoto Ueno
    A newly discovered membrane structure associates with one of the centrioles and affects two important centrosomal events in epidermal cells – ciliary positioning and spindle orientation – through a physical interaction.

Refine your results by:

Type
Research categories