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    1. Cell Biology

    Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation

    Eline Lemerle, Jeanne Lainé ... Stéphane Vassilopoulos
    Caveolae and Bin1 form tubulation platforms.
    1. Neuroscience

    Sequentially activated discrete modules appear as traveling waves in neuronal measurements with limited spatiotemporal sampling

    Yuval Orsher, Ariel Rom ... Mark Shein-Idelson
    Multi-electrode recordings and modeling work indicate that sequentially activated discrete modules of spiking neurons may appear as traveling waves in low spatial resolution measurements, suggesting caution when interpreting phase delay measurements as continuously propagating wavefronts.
    1. Computational and Systems Biology

    Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

    Morteza Chalabi Hajkarim, Ella Karjalainen ... Kyoung-Jae Won
    compaRe can be used to optimize cytometric high-parameter immunophenotypic characterization of heterogeneous cell populations.
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler, Kerry Geiler-Samerotte, Dmitri A Petrov
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
    1. Ecology

    Using aquatic animals as partners to increase yield and maintain soil nitrogen in the paddy ecosystems

    Liang Guo, Lufeng Zhao ... Xin Chen
    Aquatic animals cocultured with rice in paddy ecosystems can increase food production, improve nitrogen (N)-use efficiency, and maintain soil fertility by reducing weeds, and promoting recycle and complementary use of N.
    1. Neuroscience

    Evaluating hippocampal replay without a ground truth

    Masahiro Takigawa, Marta Huelin Gorriz ... Daniel Bendor
    A novel tool enables cross-checking the quality of replay events and evaluating the effectiveness of a given replay detection method in the absence of a ground truth.
    1. Cell Biology
    2. Developmental Biology

    Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

    Naonobu Fujita, Wilson Huang ... Amy A Kiger
    Analyses of a developmentally regulated Drosophila myofiber remodeling program provide insight into induced autophagy required for T-tubule membrane reorganization, and uncover a conserved Rab2 role in autophagosome-lysosome fusion.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance

    Rene Niehus, Esther van Kleef ... Ben S Cooper
    A data-driven within-host model reveals that different antibiotics are associated with divergent effects on antibiotic resistance carriage and abundance in hospitalised patients, with important implications for antibiotic stewardship.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    How subtle changes in 3D structure can create large changes in transcription

    Jordan Yupeng Xiao, Antonina Hafner, Alistair N Boettiger
    Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal

    Johann Mignolet, Guillaume Cerckel ... Pascal Hols
    A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.