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    1. Cell Biology
    2. Computational and Systems Biology

    Patterns of interdivision time correlations reveal hidden cell cycle factors

    Fern A Hughes, Alexis R Barr, Philipp Thomas
    Bayesian inference identifies hidden dynamics underlying noisy cell division data.
    1. Computational and Systems Biology
    2. Neuroscience

    Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans

    Rany Abend, Diana Burk ... Bruno B Averbeck
    Applying computational modeling to quantify threat learning processes uncovers how variations in these conserved learning processes relate to anxiety severity and the neuroanatomical substrates moderating these associations.
    1. Neuroscience

    Asymmetric ON-OFF processing of visual motion cancels variability induced by the structure of natural scenes

    Juyue Chen, Holly B Mandel ... Damon A Clark
    The fruit fly estimates visual motion by incorporating ON-OFF asymmetric processing that only improves performance when stimuli have light-dark asymmetries matched to natural scenes.
    1. Neuroscience

    Invariant neural subspaces maintained by feedback modulation

    Laura B Naumann, Joram Keijser, Henning Sprekeler
    Feedback-driven gain modulation provides a mechanism to generate and maintain invariant sensory representations in the presence of contextual changes by dynamically adapting feedforward sensory processing.
    1. Computational and Systems Biology
    2. Neuroscience

    Interrogating theoretical models of neural computation with emergent property inference

    Sean R Bittner, Agostina Palmigiano ... John Cunningham
    Emergent property inference, a novel machine learning methodology, learns distributions of neural circuit model parameters that produce computational properties and provides novel scientific insight through the quantification of the rich parametric structure it captures.
    1. Neuroscience

    Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models

    Menoua Keshishian, Hassan Akbari ... Nima Mesgarani
    A comprehensive, data-driven and interpretable nonlinear computational modeling framework based on deep neural networks uncovers different nonlinear transformations of speech signal in the human auditory cortex.
    1. Neuroscience

    Using adversarial networks to extend brain computer interface decoding accuracy over time

    Xuan Ma, Fabio Rizzoglio ... Ann Kennedy
    Incorporating cycle-consistency loss into a generative adversarial network creates a high-performance and robust 'aligner' of neural population activity, permitting a fixed intracortical brain computer interface to be used for months without recalibration and without requiring inference of a latent manifold.
    1. Computational and Systems Biology

    Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics

    Mayank Baranwal, Ryan L Clark ... Ophelia S Venturelli
    Recurrent neural network models enable prediction and design of health-relevant metabolite dynamics in synthetic human gut communities.
    1. Computational and Systems Biology
    2. Neuroscience

    Model discovery to link neural activity to behavioral tasks

    Jamie D Costabile, Kaarthik A Balakrishnan ... Martin Haesemeyer
    Model identification of neural encoding is an accessible system for the analysis of neural data that allows identifying and characterizing arbitrary relationships between neural activity and task-related variables such as behavior, stimuli, or internal states.
    1. Physics of Living Systems

    Hydrodynamic model of fish orientation in a channel flow

    Maurizio Porfiri, Peng Zhang, Sean D Peterson
    A hydrodynamic model of fish swimming in a channel predicts a critical flow speed for fish to successfully swim against a flow, unveiling a passive mechanism for rheotaxis to emerge without access to any sensory information.