61 results found
    1. Neuroscience

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Cian O'Donnell, J Tiago Gonçalves ... Terrence J Sejnowski
    Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
    1. Neuroscience

    Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

    Nicola Masala, Manuel Mittag ... Tony Kelly
    Common adeno-associated viral transduction procedures induce artefactual spatially confined Ca2+ waves in the hippocampus.
    1. Neuroscience

    Clustered synapses develop in distinct dendritic domains in visual cortex before eye opening

    Alexandra H Leighton, Juliette E Cheyne, Christian Lohmann
    In vivo calcium imaging in visual cortex neurons before eye opening shows that clustered synaptic inputs develop in dendritic domains, which may be precursors of computational subunits after eye opening.
    1. Neuroscience

    Network oscillation rules imposed by species-specific electrical coupling

    Stefanos Stagkourakis, Carolina Thörn Pérez ... Christian Broberger
    An unexpected species difference in electrical coupling of analogous neuroendocrine dopamine neurons in rats and mice reveals a role for gap junction connectivity as a band-pass filter for oscillation frequency in neural networks.
    1. Neuroscience

    Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

    Andrew S Blaeser, Jun Zhao ... Dan Levy
    Functional imaging of individual sensory afferents that innervate the cranial meninges in a mouse migraine model reveals heightened responsiveness to movement-related meningeal deformations that may underlie headache.
    1. Neuroscience

    Aberrant cortical activity, functional connectivity, and neural assembly architecture after photothrombotic stroke in mice

    Mischa Vance Bandet, Ian Robert Winship
    Longitudinal calcium imaging in awake mice after stroke suggests impairments in neuronal activity, functional connectivity, and neural assembly architecture is transient and limited to cortex immediately adjacent to the stroke.
    1. Cell Biology
    2. Immunology and Inflammation

    T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse

    Tobias X Dong, Shivashankar Othy ... Michael D Cahalan
    Salsa6f is a novel, ratiometric genetically encoded Ca2+ indicator that combines the power of ratiometric chemical Ca2+ indicators with the ability, when expressed transgenically, to image cellular Ca2+ signals amid complex tissue environments in vivo.
    1. Computational and Systems Biology
    2. Neuroscience

    Bi-channel image registration and deep-learning segmentation (BIRDS) for efficient, versatile 3D mapping of mouse brain

    Xuechun Wang, Weilin Zeng ... Peng Fei
    A dual-channel image registration pipeline combined with deep-learning inference achieves accurate-and-flexible registration/segmentation/mapping of mouse brain.
    1. Computational and Systems Biology

    Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population

    David Elkind, Hannah Hochgerner ... Amit Zeisel
    Across individuals of a mouse population, brain regions volumes scaled to accommodate the same amount of cells, but left hemisphere cortical regions were denser than right, and several regions of the limbic system were more pronounced in either sex.
    1. Neuroscience

    Functional and pharmacological analyses of visual habituation learning in larval zebrafish

    Laurie Anne Lamiré, Martin Haesemeyer ... Owen Randlett
    Complex and distributed plasticity processes are revealed by a functional and pharmacological analysis of visual habituation learning in larval zebrafish.

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