Prostaglandin E2-mediated radial spread of PKA activation, caused by calcium transients, is a novel mode of intercellular communication in living mice.
William T Redman, Nora S Wolcott ... Michael J Goard
Two-photon imaging through glass microperiscopes allows imaging of the transverse plane of the hippocampus, including all major subfields, in awake behaving mice.
Tobias X Dong, Shivashankar Othy ... Michael D Cahalan
Orai1 channels activate intermittently in motile T cells, generating calcium transients, detected by a novel genetically encoded indicator and inducing pauses that favor antigen scanning.
Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
Juan Carlos Boffi, Brice Bathellier ... Robert Prevedel
Bespoke volumetric calcium imaging, validated with neuropixels recordings, evidence a population code for sound azimuth at the dorsal cortex of the inferior colliculus, with a contribution of noise correlations.
Simonas Griesius, Amy Richardson, Dimitri Michael Kullmann
NMDA receptors mediate prominent supralinear summation of clustered excitatory inputs to the dendrites of neurogliaform and oriens-lacunosum moleculare interneurons of the hippocampus, showing that these cells perform sub-cellular computations.
In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integration of time and space.
