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    1. Neuroscience

    Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses

    Bernard Bloem et al.
    Simultaneous 2-photon imaging of striosomes and matrix in mice shows that striosomes preferentially encode reward-predicting cues whereas both striatal compartments demonstrate reward-related activity.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging

    Nicholas James Sofroniew et al.
    An optical microscopy approach with an ultra-large field of view but retained subcellular resolution allows simultaneous imaging of neural activity in widely dispersed brain regions.
    1. Cell Biology
    2. Developmental Biology

    Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

    Kiersten A Henderson et al.
    Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
    1. Neuroscience

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Cian O'Donnell et al.
    Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
    1. Neuroscience

    Tonotopic and non-auditory organization of the mouse dorsal inferior colliculus revealed by two-photon imaging

    Aaron Benson Wong, J Gerard G Borst
    A spatial analysis of auditory and non-auditory properties of excitatory and inhibitory neurons in the mouse dorsal inferior colliculus defines the border between the lateral and the dorsal cortex.
    1. Neuroscience

    Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

    Vanessa Lage-Rupprecht et al.
    The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.
    1. Neuroscience

    Clustered functional domains for curves and corners in cortical area V4

    Rundong Jiang et al.
    Curves and corners are separately encoded by neurons clustered into functional domains in macaque V4.
    1. Neuroscience

    CaImAn an open source tool for scalable calcium imaging data analysis

    Andrea Giovannucci et al.
    CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
    1. Neuroscience

    Complexity of frequency receptive fields predicts tonotopic variability across species

    Quentin Gaucher et al.
    The A1 of ferrets and mice show similar tonotopic organizations, with neurons preferring a single frequency being more precisely organized into a tonotopic map than multipeaked neurons.
    1. Neuroscience

    Synchronous activity patterns in the dentate gyrus during immobility

    Martin Pofahl et al.
    Two-photon in vivo calcium imaging reveals short time-scale, synchronous and sparse population activity in dentate gyrus that replays place-related information, and is important for formation of dentate-dependent spatial memory.