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    1. Structural Biology and Molecular Biophysics

    Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove

    Christina A Stephens, Niek van Hilten ... Michael Grabe
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Inadequate
    1. Medicine
    2. Neuroscience

    mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

    Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Probing the force-from-lipid mechanism with synthetic polymers

    Miranda L Jacobs, Jan Steinkühler ... Neha P Kamat
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology

    Coordinated regulation of chemotaxis and resistance to copper by CsoR in Pseudomonas putida

    Meina He, Yongxin Tao ... Wenli Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    Capsular polysaccharide restrains type VI secretion in Acinetobacter baumannii

    Nicolas Flaugnatti, Loriane Bader ... Melanie Blokesch
    Capsular polysaccharides of Acinetobacter baumannii regulate type VI secretion system activity, balancing self-protection with interbacterial competitiveness.
    1. Cell Biology

    Hypersensitive intercellular responses of endometrial stromal cells drive invasion in endometriosis

    Chun-Wei Chen, Jeffery B Chavez ... Bruce J Nicholson
    A unique functional comparison of the major endometrial cell types from 44 control and endometriosis patients demonstrates not only a uterine origin of the disease, but also that endometrial to mesothelial cell gap junctions are required for invasive lesion formation.
    1. Neuroscience

    Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells

    Dominic Gonschorek, Matías A Goldin ... Thomas Euler
    Nitric oxide is a type-selective neuromodulator affecting the temporal, but not the spatial response kinetics of a specific subset of mouse retinal ganglion cells.
    1. Neuroscience

    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    Arnaud PJ Giese, Wei-Hsiang Weng ... Zubair M Ahmed
    Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.
    1. Neuroscience

    Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism

    Susan Lin, Aravind R Gade ... Geoffrey S Pitt
    Variants in FGF13, associated with developmental and epileptic encephalopathies, alter neuronal excitability by affecting inhibitory neurons and by a sodium channel-independent mechanism.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dissociation of the nuclear basket triggers chromosome loss in aging yeast

    Mihailo Mirkovic, Jordan McCarthy ... Yves Barral
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
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