Pancreatic α and β cells have different cell autonomous signatures; this explains why α but not β cells can clear infections by potentially diabetogenic viruses.
Botond Antal, Liam P McMahon ... Lilianne R Mujica-Parodi
Patients with Type 2 diabetes show patterns of neurodegeneration consistent with accelerated brain aging, including impaired cognition and loss of brain volume, which are more severe in those with increased disease duration.
Computational methods were used to develop accurate manual scorecards for early detection of participants at risk of type 2 diabetes based on the UK Biobank database.
Risheng Ye, William L Holland ... Philipp E Scherer
Under insulinopenic conditions, the hormone adiponectin is essential for lipid uptake specifically in subcutaneous white adipose tissue, and is sufficient to ameliorate islet lipotoxicity.
Guangliang Wang, Surendra K Rajpurohit ... Jeff S Mumm
A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.
Cells from the human pancreatic duct can be grown in culture and triggered to become insulin-producing cells, which could potentially be transplanted into patients with diabetes.
Cardiac intercellular communication plays a critical role in diabetic myocardial fibrosis and specific targeting of Hrchi fibroblasts may be a potential therapeutic target for diabetic cardiomyopathy.
