210 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding et al.
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

    Pornchai Kaewsapsak et al.
    Live-cell nanometer-resolution RNA labeling method enables transcriptome-wide mapping of endogenous RNAs in nuclear, cytosol, ER, and mitochondrial subcompartments.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Epidemiology and Global Health

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng et al.
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.
    1. Developmental Biology
    2. Evolutionary Biology

    Domestic chickens activate a piRNA defense against avian leukosis virus

    Yu Huining Sun et al.
    To protect the germ line genome, chickens acquire new small RNA-based immune defense in response to recently endogenized retroviruses by turning a truncated provirus into a weapon.
    1. Biochemistry and Chemical Biology

    Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

    Victoria Juskaite et al.
    Ligand binding induces DDR1 kinase activity through recruitment of DDR1 receptors into signalling clusters in which phosphorylation occurs across different dimers.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao et al.
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.

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