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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles

    Mahta Barekatain, Yameng Liu ... Mark A Hayes
    An unbiased separation method reveals distinct subpopulations of insulin secretory vesicles that undergo dynamic remodeling upon glucose stimulation.
    1. Cell Biology
    2. Neuroscience

    APOE expression and secretion are modulated by mitochondrial dysfunction

    Meghan E Wynne, Oluwaseun Ogunbona ... Victor Faundez
    Current models of Alzheimer's disease that put mitochondria as an endpoint of disease should be reconsidered because genetic defects affecting mitochondria by themselves can also regulate Alzheimer’s disease risk factor apolipoprotein E (APOE) expression and secretion.
    1. Cell Biology

    Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

    Thomas M Rawlings, Komal Makwana ... Emma S Lucas
    The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.
    1. Microbiology and Infectious Disease

    A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

    Sofiene Seef, Julien Herrou ... Tâm Mignot
    First identification of the molecular determinants driving contact-dependent predation in Myxococcus..
    1. Microbiology and Infectious Disease

    An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey, Brad E Sleebs ... Christopher J Tonkin
    The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang, Wenju Sun ... Jian Yan
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Developmental Biology
    2. Immunology and Inflammation

    Symbiont-induced odorant binding proteins mediate insect host hematopoiesis

    Joshua B Benoit, Aurélien Vigneron ... Brian L Weiss
    Insect symbiotic bacteria regulate expression of an odorant binding protein that mediates an evolutionarily conserved hematopoietic pathway crucial for host immune system development and function.
    1. Immunology and Inflammation

    Self-inhibiting percolation and viral spreading in epithelial tissue

    Xiaochan Xu, Bjarke Frost Nielsen, Kim Sneppen
    A gene expression data-informed model reveals that a small fraction of interferon-producing cells can effectively constrain early virus spread in epithelial tissue, elucidating connections between critical dynamics and infection heterogeneity.
    1. Microbiology and Infectious Disease

    Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

    Andrew A Bridges, Bonnie L Bassler
    The global pathogen Vibrio cholerae monitors environmental polyamines to garner information about numbers of ‘self’ versus ‘other’ in the vicinity, and in response, to remain or disperse from biofilms.
    1. Physics of Living Systems

    Quantifying gliding forces of filamentous cyanobacteria by self-buckling

    Maximilian Kurjahn, Antaran Deka ... Stefan Karpitschka
    The self-buckling behavior of filamentous cyanobacteria allowed a quantification of their propulsion forces, indicating that adhesion plays an important role in gliding motility.