864 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

    Qi Wang et al.
    A key B-cell tyrosine kinase that adopts an autoinhibited conformation, and can be activated by either membrane recruitment or soluble inositol hexakisphosphates in solution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

    Huaibin Chen et al.
    A four-switch long-range allosteric network controls FGF receptor kinase conformational dynamics as well as activity and is applicable to other receptor tyrosine kinases.
    1. Neuroscience

    Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors

    Gabriella R Sterne et al.
    Targeting Abelson kinase can be beneficial for treating disorders characterized by dysregulated Down Syndrome Cell Adhesion Molecule signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

    Joshua A Jadwin et al.
    The recruitment of SH2-containing proteins to Epidermal Growth Factor in cells happens more slowly than predicted by in vitro techniques.
    1. Cell Biology

    Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy

    Louise A Moyle et al.
    Rescue of DUX4-induced muscle pathology by the RET inhibitor Sunitinib reveals the therapeutic potential for treatment of Facioscapulohumeral muscular dystrophy using tyrosine kinase inhibitors.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

    Erin D Lew et al.
    Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

    Neel H Shah et al.
    A high-throughput technique to characterize the substrate specificities of tyrosine kinases identifies the key features of kinases and substrates that enforce accurate signaling from T cell receptors.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

    Jie Li et al.
    Cryo-EM studies reveal structural basis for the activation, auto-inhibition and regulation of RET receptor tyrosine kinase.
    1. Developmental Biology

    Abelson tyrosine-protein kinase 2 regulates myoblast proliferation and controls muscle fiber length

    Jennifer K Lee et al.
    Abl2 regulates myoblast proliferation, thereby controlling the size of the pool of myoblasts available for fusion, providing insight into mechanisms that control myofiber length and signaling between muscle and tendon.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk

    Daniela Justa-Schuch et al.
    Cleavage of Syk, a central kinase in B-cell signalling, by DPP9 leads to Syk degradation, identifying novel roles for DPP9 in Syk signaling and in the N-end rule pathway.

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