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    1. Biochemistry and Chemical Biology

    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

    Vidyasiri Vemulapalli et al.
    Monitoring SHP2 phosphoproteome dynamics identifies new substrate sites and sites protected from dephosphorylation by its SH2 domains, highlighting distinct scaffolding and catalytic activities in effecting a transmembrane signaling response.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

    Nicole Hajicek et al.
    The high-resolution X-ray crystal structure of PLC-γ1 reveals a unifying model for the regulation of the PLC-γ isozymes.
    1. Cell Biology
    2. Computational and Systems Biology

    EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

    Martin Baumdick et al.
    Plasticity arising from autocatalytic receptor activation coexists with robustness in ligand responsiveness only by differential endosomal sorting of spontaneous and ligand-activated EGFR as distinct molecular states.
    1. Cell Biology
    2. Computational and Systems Biology

    CDK control pathways integrate cell size and ploidy information to control cell division

    James Oliver Patterson et al.
    DNA concentration, cyclin levels, phosphatase activity, and CDK phosphorylation combine to directly link cell size to cell division.
    1. Cell Biology

    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

    Minseong Kim et al.
    HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

    Bert van de Kooij et al.
    The human NimA-related kinases (Neks) recognize divergent substrate motifs, and include Nek10 as a dual-specificity serine/tyrosine kinase, and Nek6, Nek7 and Nek9 as amplifiers of the Plk1 phospho-motif.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

    Neel H Shah et al.
    A high-throughput comparison of substrate specificities of the Src-family kinases Lck and c-Src against a library of proteome-derived phosphorylation sites reveals that Lck has evolved divergent electrostatic features reflecting its involvement in T-cell signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

    Joshua A Jadwin et al.
    The recruitment of SH2-containing proteins to Epidermal Growth Factor in cells happens more slowly than predicted by in vitro techniques.
    1. Biochemistry and Chemical Biology

    Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

    Joshua E Mayfield et al.
    The phosphorylation of tyrosine in the heptad repeat of the C-terminal domain of the largest subunit of RNA polymerase II promotes Ser2 phosphorylation by P-TEFb for pausing release.
    1. Neuroscience

    A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

    Guanglin Xing et al.
    Asparagine 88 to lysine (N88K), a prevalent congenital myasthenic syndrome mutation of Rapsyn, impairs the neuromuscular junction by disrupting agrin signaling.