242 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Operon mRNAs are organized into ORF-centric structures that predict translation efficiency

    David H Burkhardt et al.
    Operonic mRNAs in bacteria are comprised of ORF (open reading frame)-wide units of secondary structure, which are intrinsically distinct between adjacent ORFs and encode a rough blueprint for ORF-specific translation efficiency.
    1. Chromosomes and Gene Expression

    Gene regulation: A transcriptional switch controls meiosis

    A Elizabeth Hildreth, Karen M Arndt
    A key protein involved in the segregation of meiotic chromosomes is produced 'just in time' by the regulated expression of two mRNA isoforms.
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    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

    Anil Raj et al.
    Over 7,000 novel translated sequences have been identified from human cells, including several hundred in annotated noncoding RNA, pseudogenes and de novo assembled transcripts.
    1. Chromosomes and Gene Expression

    Kinetochore inactivation by expression of a repressive mRNA

    Jingxun Chen et al.
    Rather than being a protein coding unit, an mRNA molecule can serve a purely regulatory function to inhibit protein synthesis of its corresponding gene.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

    Hiromi Maekawa et al.
    Cdc5-dependent SPB regulation is linked to delayed cytoplasmic microtubule organization in Ogataea polymorpha.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent maintenance of ER topology

    Sumit Pawar et al.
    Efficient targeting of membrane proteins from the endoplasmic reticulum (ER) to the inner nuclear membrane depends on GTP hydrolysis by Atlastin GTPases and their function in maintaining an interconnected topology of the ER network.
    1. Chromosomes and Gene Expression

    The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA

    Rachael Di Santo et al.
    The unspliced HAC1 mRNA does not give rise to detectable protein in budding yeast, despite its cytoplasmic localization, due to a two-part post-transcriptional silencing mechanism.
    1. Immunology and Inflammation

    Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

    Alexandria C Wells et al.
    TCR-mediated downregulation of let-7 microRNAs licenses the differentiation of activated CD8 T cells into cytotoxic T lymphocytes.
    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele et al.
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation

    Sylvain Durand et al.
    Small regulatory RNAs are able to modulate mRNA degradation rates by controlling access to the 5' end of mRNAs in bacteria.

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