353 results found
    1. Microbiology and Infectious Disease

    Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1

    Hongbing Jiang et al.
    Genetic and biochemical analyses identify a pathway important for infection by many picornaviruses.
    1. Neuroscience

    Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila

    Ane Martin Anduaga et al.
    Temperature controls the circadian clock by directly regulating the alternative splicing of timeless..
    1. Chromosomes and Gene Expression

    An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

    Irene Díaz-López et al.
    The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
    1. Cell Biology

    Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila

    Johanna Lattner et al.
    The polarity protein crumbs controls apical secretion and the architecture of the apical domain by modulating PI(4,5)P2 levels and the organization of apical Rab6-, Rab11-, and Rab30-dependent trafficking.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors

    John Frederick Beckmann et al.
    Genetic and proteomic screening with Wolbachia's CidB enzyme reveal the mechanisms and targets of cytoplasmic incompatibility (CI).
    1. Biochemistry and Chemical Biology

    Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases

    Priyesh Mohanty et al.
    Post-translational modifications regulate transient protein-protein interactions to disrupt Ubiquitin enzyme/ligase complexes, a strategy used by Shigella to inactivate the host immune response.
    1. Cell Biology

    Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

    Yilin Kang et al.
    A neuronal specific function of the mitochondrial chaperone, hTim8a in Complex IV biology provides insight into the pathomechanisms underlying the mitochondrial disease, Mohr-Tranebjaerg syndrome.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

    Arunava Roy et al.
    The innate immune DNA sensor IFI16 is in association with H3K9 methyltransferases SUV39H1 and GLP under physiological conditions in the nucleus which facilitates the epigenetic silencing of foreign viral DNA.
    1. Cell Biology
    2. Evolutionary Biology

    A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

    Omaya Dudin et al.
    Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
    1. Developmental Biology

    Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila

    Zong-Heng Wang et al.
    An insulin-Myc feed-forward loop triggered by transient JNK boosts transcription of genes essential for mitochondrial respiration and biogenesis during early oogenesis to support massive mtDNA replication and inheritance in Drosophila.

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