750 results found
    1. Microbiology and Infectious Disease

    Functional insights from a surface antigen mRNA-bound proteome

    Larissa Melo do Nascimento et al.
    A robust procedure to purify mRNAs and their associated proteins identify CFB2 as the critical protein that binds and influences the fate of the main virulence factor in Trypanosoma brucei.
    1. Cell Biology
    2. Developmental Biology

    A polarity pathway for exocyst-dependent intracellular tube extension

    Joshua Abrams, Jeremy Nance
    Lumen extension in intracellular tubes relies on a molecular pathway involving Rho GTPase signaling, cell polarity, and vesicle-tethering proteins.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication

    Agnieszka Fatalska et al.
    The dual functional protein, Gorab, associates with the Golgi as a dimer but as a monomer with the procentriole cartwheel protein, Sas6, to mediate centriole duplication.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Dynamic Na+/H+ exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

    Lise M Sjøgaard-Frich et al.
    NHE1-CaM complexes of multiple stoichiometries regulate cellular Ca2+-dependent NHE1 activity and can contribute to NHE1 dimerization, the latter shown by the NMR structure of CaM linking two NHE1 cytosolic tails.
    1. Plant Biology

    Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants

    Philipp Schwenk et al.
    The light-activated plant photoreceptor phytochrome A binds to NOT9B to displace it from the CCR4-NOT complex, thereby de-repressing light signalling.
    1. Structural Biology and Molecular Biophysics

    Switch-like control of helicase processivity by single-stranded DNA binding protein

    Barbara Stekas et al.
    A single-stranded DNA binding protein stimulates helicase-mediated DNA unwinding by transiently activating a latent processivity switch in the helicase.
    1. Cell Biology

    A nuclear-based quality control pathway for non-imported mitochondrial proteins

    Viplendra PS Shakya et al.
    During times of mitochondrial impairment, non-imported mitochondrial precursor proteins are targeted to the nucleus for proteasome-dependent degradation.
    1. Cell Biology
    2. Plant Biology

    SABRE populates ER domains essential for cell plate maturation and cell expansion influencing cell and tissue patterning

    Xiaohang Cheng, Magdalena Bezanilla
    SABRE, which is present in a wide range of eukaryotes, localizes to ER subdomains in plants, impacting cell expansion and callose deposition during cell plate maturation.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi et al.
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Neuroscience

    Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

    Inés González-Calvo et al.
    SUSD4 loss-of-function induces misregulation of GLUA2 degradation and of synaptic plasticity suggesting a mechanism for its potential contribution to neurodevelopmental disorders.

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