Browse the search results

Page 3 of 8
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Affimer proteins are versatile and renewable affinity reagents

    Christian Tiede et al.
    The Affimer technology represents renewable binding reagents for molecular biology, which provides research scientists and industry with an alternative to the recently criticised use of animal-produced antibodies.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu et al.
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Cell Biology
    2. Developmental Biology

    Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome

    Katherine Young Bezold Lamm et al.
    Loss of Inverted Formin-2 impairs intracellular trafficking and trophoblast invasion, resulting in maternal hypertension and intrauterine growth restriction, which represents a novel model of impaired placental invasion that encompasses critical aspects of the great obstetrical syndromes.
    1. Cell Biology
    2. Immunology and Inflammation

    Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo

    Asif J Iqbal et al.
    Mechanistic insights show how treatment with apoA1 is anti-inflammatory by rapidly disrupting macrophage chemotaxis and monocyte recruitment.
    1. Developmental Biology

    Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

    Man Chu et al.
    Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.
    1. Developmental Biology

    Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

    Maria V Gelfand et al.
    Interactions between Neuropilin-1 and VEGFR2, rather than VEGF-Neuropilin-1 binding, underlie Neuropilin-1's critical function in VEGF-mediated vascular development.
    1. Evolutionary Biology

    The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions

    Alessandro W Rossoni et al.
    Horizontal gene transfer (HGT) analysis in polyextremophile red algae (Cyanidiales) provides explanations for the nonexistence of cumulative effects and eukaryotic pangenomes, and highlights differences between HGT and native genes.
    1. Cell Biology
    2. Developmental Biology

    CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

    Myo-Hyeon Park et al.
    Cyr61 autoregulating tip cell activity by interlinking integrin and Hippo pathway and targeting Cyr61 provides promising therapeutic approach for the treatment of pathological angiogenesis, including tumour angiogenesis.
    1. Epidemiology and Global Health

    External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh

    Malia SQ Murphy et al.
    Gestational age estimation models derived from newborn screening bloodspot samples are effective on data obtained from both heel prick and cord blood samples in low-resource settings.
    1. Stem Cells and Regenerative Medicine

    Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

    Isabelle Bergiers et al.
    Single-cell transcriptomics analysis identifies the dynamic activity of transcription factors at the onset of hematopoeitic stem and progenitor cells formation during embryonic development.