2,923 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density

    Ellie Sherrard-Smith et al.
    Combining pre-erythrocytic and transmission blocking antibodies enhances the overall control and potential elimination of malaria within both mosquito and vertebrate populations.
    1. Neuroscience

    Lateral orbitofrontal neurons acquire responses to upshifted, downshifted, or blocked cues during unblocking

    Nina Lopatina et al.
    Building on previous work (McDannald et. al, 2014), it is shown that dissociable populations of neurons in the lateral orbitofrontal cortex acquire responses to cues that predict more, less, or no change in reward in rats during training in a Pavlovian unblocking task.
    1. Neuroscience

    Orbitofrontal neurons acquire responses to ‘valueless’ Pavlovian cues during unblocking

    Michael A McDannald et al.
    Orbitofrontal cortex neurons fire in response to cues with no value independent of what can be inferred through features of the predicted outcome.
    1. Cancer Biology

    SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer

    Ziling Fang et al.
    SPIN1, a nucleolar protein, plays an oncogenic role by suppressing the tumor suppressor p53's function via regulation of the uL18-MDM2-p53 pathway.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Lis1 regulates dynein by sterically blocking its mechanochemical cycle

    Katerina Toropova et al.
    Structural and functional studies reveal how a ubiquitous regulator of dynein keeps the microtubule-based motor in a persistent track-bound state.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang et al.
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Thalidomide: Unlocking a dark past

    Fernando Rodríguez-Pérez, Michael Rape
    A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.
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    1. Neuroscience

    Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

    Zohreh Farsi et al.
    Parallel measurements of pH gradient and membrane potential at the single vesicle level have revealed that the synaptic vesicle acidification is initiated by removal of its clathrin coat, which blocks vesicular ATPase activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

    Roni M Lahr et al.
    La-related protein 1 specifically and directly binds the 5' cap and first nucleotide of mRNAs encoding ribosomal proteins and translation factors, inhibiting the assembly of translation initiation factors on these messages and therefore their translation.

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