1,250 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Waveform detection by deep learning reveals multi-area spindles that are selectively modulated by memory load

    Maryam H Mofrad, Greydon Gilmore ... Lyle Muller
    A new computational approach for detecting sleep waveforms reveals that the 11–15 Hz sleep 'spindle', a neural rhythm implicated in memory consolidation, co-occurs widely across cortex much more often than previously thought.
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

    Matthew T Parker, Beth K Soanes ... Gordon G Simpson
    High throughput sequencing of Arabidopsis mutants lacking the U6 snRNA methyltransferase FIONA1/METTL16 uncovers the role of U6 methylation in splicing signal preferences.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance

    Erida Gjini, Kevin B Wood
    A simple mathematical model reveals that antibiotic interactions and collateral effects of evolution are inseparable drivers of multidrug resistance linked by the well-known Price equation from evolutionary theory.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Tunable molecular tension sensors reveal extension-based control of vinculin loading

    Andrew S LaCroix, Andrew D Lynch ... Brenton D Hoffman
    A quantitative understanding of molecular tension sensor function enables the production of unique sensors with desired mechanical properties as well as the ability to distinguish between protein force and protein deformation in mechanosensitive processes.
    1. Neuroscience

    Induced sensorimotor cortex plasticity remediates chronic treatment-resistant visual neglect

    Jacinta O'Shea, Patrice Revol ... Yves Rossetti
    Tonic disinhibition of left motor cortex during prism adaptation enhanced consolidation of sensorimotor and cognitive prism after effects, causing lasting clinical gains in three patient cases with chronic treatment-resistant visual neglect.
    1. Computational and Systems Biology
    2. Neuroscience

    Natural-gradient learning for spiking neurons

    Elena Kreutzer, Walter Senn, Mihai A Petrovici
    A parametrization-invariant synaptic plasticity rule based on natural-gradient descent leads to multiple predictions for the biological plasticity process, some of which relate to well-studied phenomena such as heterosynaptic plasticity.
    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
    1. Computational and Systems Biology

    The functional form of value normalization in human reinforcement learning

    Sophie Bavard, Stefano Palminteri
    Challenging a popular theory in neuroeconomics, a computational cognitive study provides evidence against divisive normalization, a supposedly canonical neural computation, in favor of an alternative account, range normalization, in the context of value learning.

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