1,250 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

    Daniel B Larremore, Bailey K Fosdick ... Yonatan H Grad
    Integrating over multiple forms of statistical uncertainty associated with serological surveys can improve serosurvey design while also enabling that uncertainty to be appropriately propagated through epidemiological models.
    1. Neuroscience

    Flexible and efficient simulation-based inference for models of decision-making

    Jan Boelts, Jan-Matthis Lueckmann ... Jakob H Macke
    A new machine learning method makes it possible to efficiently identify the parameters of cognitive models using Bayesian inference, even when only model simulations are available.
    1. Computational and Systems Biology

    A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates

    Dennis Wang, James Hensman ... Frank Dondelinger
    Quantification of uncertainty in drug dose-responses provides a more robust metric for differentiating drugs and identifying biomarkers of response.
    1. Neuroscience

    Introducing µGUIDE for quantitative imaging via generalized uncertainty-driven inference using deep learning

    Maëliss Jallais, Marco Palombo
    µGUIDE is a Bayesian framework that leverages simulation-based inference to efficiently estimate posterior distributions of any forward model parameters, allowing for uncertainty quantification and degeneracy detection.
    1. Neuroscience

    Hyperreactivity to uncertainty is a key feature of subjective cognitive impairment

    Bahaaeddin Attaallah, Pierre Petitet ... Masud Husain
    Analysis of performance on a novel behavioural paradigm investigating active information gathering reveals that subjective cognitive impairment is associated with hyperreactivity to uncertainty and links this mechanism to the affective burden in the condition and heightened insular-hippocampal connectivity.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Consistent and correctable bias in metagenomic sequencing experiments

    Michael R McLaren, Amy D Willis, Benjamin J Callahan
    A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
    1. Neuroscience

    Using the past to estimate sensory uncertainty

    Ulrik Beierholm, Tim Rohe ... Uta Noppeney
    For perceptual inference, human observers do not estimate sensory uncertainty instantaneously from the current sensory signals alone, but by combining past and current sensory inputs consistent with a Bayesian learner.
    1. Neuroscience

    Visually-updated hand state estimates modulate the proprioceptive reflex independently of motor task requirements

    Sho Ito, Hiroaki Gomi
    Distortion and elimination of limb visual feedback affects low-level stretch reflex control, indicating the involvement of a high-level and multimodal representation of the limb state in orchestrating hierarchical sensorimotor control.
    1. Computational and Systems Biology
    2. Neuroscience

    Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows

    Olivia Eriksson, Upinder Singh Bhalla ... Jeanette Hellgren Kotaleski
    Increased usability and validity of neuroscience models, through FAIR workflows for the whole modeling process, including data and model management, parameter estimation, uncertainty quantification, and model analysis.
    1. Neuroscience

    Sampling motion trajectories during hippocampal theta sequences

    Balazs B Ujfalussy, Gergő Orbán
    The rodent brain represents uncertainty associated with short-term predictions during naturalistic navigation tasks sequentially by sampling hypothetical future trajectories in every ~100 ms, corresponding to successive theta cycles.

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