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    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Bayesian inference of kinetic schemes for ion channels by Kalman filtering

    Jan L Münch, Fabian Paul ... Klaus Benndorf
    For analyzing time-dependent patch-clamp or patch-clamp fluorometry data of ion channels in terms of Markovian models, the superiority of Bayesian filtering with respect to traditional deterministic approaches is demonstrated enabling more reliable quantification of the parameters.
    1. Epidemiology and Global Health

    Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate

    Benjamin Amoah, Robert S McCann ... Emanuele Giorgi
    Estimating fine-scale spatiotemporal patterns of Plasmodium falciparum transmission showed an association between entomological inoculation rate and parasite prevalence that emphasizes the value of both measures in malaria surveillance.
    1. Neuroscience

    Bayesian inference of population prevalence

    Robin AA Ince, Angus T Paton ... Philippe G Schyns
    Bayesian estimation of the proportion of the population that would show an effect in an experiment provides a broadly applicable alternative to standard null hypothesis tests on the population mean with several advantages.
    1. Epidemiology and Global Health
    2. Medicine

    Estimates of the global burden of Japanese encephalitis and the impact of vaccination from 2000-2015

    Tran Minh Quan, Tran Thi Nhu Thao ... Hannah Clapham
    Modelling analysis reveals the burden of Japanese Encephalitis is greater than previously thought, and although vaccination has reduced burden, there are remaining places with a great need for vaccination.
    1. Computational and Systems Biology
    2. Neuroscience

    Training deep neural density estimators to identify mechanistic models of neural dynamics

    Pedro J Gonçalves, Jan-Matthis Lueckmann ... Jakob H Macke
    Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.
    1. Cell Biology
    2. Immunology and Inflammation

    Nanoscale binding site localization by molecular distance estimation on native cell surfaces using topological image averaging

    Vibha Kumra Ahnlide, Johannes Kumra Ahnlide ... Pontus Nordenfelt
    A method to carefully measure the molecular distance between a site of interest and a reference surface by the repeated acquisition of the two image channels followed by the statistical calculation of the relative difference.
    1. Neuroscience

    Putting perception into action with inverse optimal control for continuous psychophysics

    Dominik Straub, Constantin A Rothkopf
    A new method for analyzing continuous psychophysics experiments estimates not only perceptual uncertainty from tracking tasks but also action variability, intrinsic costs, and subjective internal models.
    1. Neuroscience

    Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

    Lorenz Deserno, Rani Moran ... Raymond J Dolan
    Cooperation between model-free and model-based control systems is boosted by enhancing dopamine levels.
    1. Neuroscience

    Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

    Karima Chakroun, David Mathar ... Jan Peters
    Dopamine attenuates exploration during decision-making via a reduction of neural tracking of uncertainty.
    1. Epidemiology and Global Health

    Early analysis of the Australian COVID-19 epidemic

    David J Price, Freya M Shearer ... James M McCaw
    An analysis of Australian case data demonstrates how the combined strategy of border measures, case targeted interventions, and social distancing effectively contained the first epidemic wave of COVID-19.