1,095 results found
    1. Cell Biology

    ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion

    Amy J Curwin et al.
    The release of Acb1 protein from yeast cells requires the ESCRT-III complex to stabilize the compartment for unconventional protein secretion (CUPS).
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

    Julia P Steringer et al.
    The first reconstitution of an unconventional secretory mechanism uncovered the molecular mechanism by which Fibroblast Growth Factor 2 is secreted from mammalian cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

    Min Zhang et al.
    Reconstitution of interleukin-1β secretion in non-macrophage cells implicates how this pro-inflammatory cytokine enters into the unconventional pathway of secretion through autophagy.
  1. Tutorial: How to draw the line in biomedical research

    Lisa Huang et al.
    When analysing the data in a two-dimensional scatter plot, researchers should consider plotting the three regression lines that can be calculated for such a plot.
    1. Epidemiology and Global Health

    Science Forum: Unit of analysis issues in laboratory-based research

    Nick R Parsons et al.
    A simulation study is used to demonstrate how mistakes in identifying the experimental unit and the unit of analysis can lead to incorrect analyses and inappropriate inferences when reporting research studies.
  2. Cutting Edge: Science hackathons for developing interdisciplinary research and collaborations

    Derek Groen, Ben Calderhead
    Science hackathons can help academics, particularly those in the early stage of their careers, to build collaborations and write research proposals.
  3. Meta-Research: Tracking the popularity and outcomes of all bioRxiv preprints

    Richard J Abdill, Ran Blekhman
    Data are reported for the monthly number of uploads to and downloads from bioRxiv, and for the number of preprints that are later published in peer-reviewed journals.
    1. Human Biology and Medicine

    Book Review: Bad medicine

    Richard Smith
    In his new book Ben Goldacre argues that the pharmaceutical industry is in poor health and in urgent need of treatment.
    1. Human Biology and Medicine

    Science Forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research

    Nicholas GD Masca et al.
    The RIPOSTE framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies.

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