26 results found
    1. Physics of Living Systems

    Swimming eukaryotic microorganisms exhibit a universal speed distribution

    Maciej Lisicki, Marcos F Velho Rodrigues ... Eric Lauga
    Analysis of published studies reveals that flagellates and ciliates separately exhibit log-normal distributions of swimming speeds, and rescaling by the mean speed of each collapses them to a universal relationship.
    1. Neuroscience

    Two conserved vocal central pattern generators broadly tuned for fast and slow rates generate species-specific vocalizations in Xenopus clawed frogs

    Ayako Yamaguchi, Manon Peltier
    Although courtship vocalizations are unique to each species, the basic architecture of the neural circuitries underlying this behavior is conserved among closely related species of frogs, suggesting behavior can diverge while utilizing the homologous neural network inherited through evolutionary lineage.
    1. Computational and Systems Biology
    2. Neuroscience

    Self-configuring feedback loops for sensorimotor control

    Sergio Oscar Verduzco-Flores, Erik De Schutter
    Learning to reach in the sensorimotor loop, and the required neural dynamics, can be potentially explained by simple principles.
    1. Developmental Biology
    2. Evolutionary Biology

    The evolutionary origin of bilaterian smooth and striated myocytes

    Thibaut Brunet, Antje HL Fischer ... Detlev Arendt
    Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.
    1. Developmental Biology
    2. Neuroscience

    The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

    Sebastián Giunti, María Gabriela Blanco ... Diego Rayes
    PTEN mutations disrupt inhibitory GABAergic signaling, causing neurodevelopmental defects that can be mitigated by β-hydroxybutyrate, which activates DAF-16/FOXO and may offer a therapeutic approach for excitation/inhibition imbalances.
    1. Computational and Systems Biology
    2. Neuroscience

    Integrative neuromechanics of crawling in D. melanogaster larvae

    Cengiz Pehlevan, Paolo Paoletti, L Mahadevan
    An integrative model of coordinated crawling in fruit fly maggots links neuromuscular dynamics to body-substrate mechanics in the presence of proprioceptive feedback.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto, Yohei Matsunaga ... Hang Lu
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Cell Biology
    2. Neuroscience

    Desmosomal connectomics of all somatic muscles in an annelid larva

    Sanja Jasek, Csaba Verasztó ... Gáspár Jékely
    Volume-EM reconstruction of a whole-body desmosomal connectome including all muscles and their desmosomal partners in a Platynereis larva provides a detailed view of the organisation of the entire locomotor system in an animal.
    1. Neuroscience

    Modeling spinal locomotor circuits for movements in developing zebrafish

    Yann Roussel, Stephanie F Gaudreau ... Tuan V Bui
    Computational models of spinal locomotor circuits in developing zebrafish reveal how new movements can emerge during development through the integration of new spinal neurons and new connections.
    1. Evolutionary Biology

    Spinosaurus is not an aquatic dinosaur

    Paul C Sereno, Nathan Myhrvold ... Lauren L Conroy
    A digital flesh model of the sail-backed dinosaur Spinosaurus was tested and performed very poorly in water, favoring the view of this dinosaur as a two-legged, wading ambush predator of large fish in shallow waterways and not an aquatic dinosaur.

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