392 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)

    Joshua J Filter et al.
    Unfair competition, in which a phosphatase and a phosphoprotein inhibitor/substrate mutually sequester each other from competing substrates and enzymes, is a conserved mechanism for the control of PPP family phosphatases.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

    Byron C Williams et al.
    The mechanism of inhibition by unfair competition is central to determining the protein phosphorylation states that govern cell cycle transitions between M phase and interphase.
  1. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
  2. Point of View: Correcting the bias against interdisciplinary research

    Ehud Shapiro
    When making decisions about funding and jobs the scientific community should recognise that most of the tools used to evaluate scientific excellence are biased in favour of established disciplines and against interdisciplinary research.
  3. Careers: eLife and early career researchers

    Randy Schekman et al.
    There are many reasons for submitting your best work to eLife, especially if you are an early career researcher.
    Editorial
    Available as:
    • HTML
    • PDF
  4. Point of View: Science, art, society and Klimt’s University of Vienna paintings

    Alberto E Pereda
    A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.
  5. Point of View: Priority of discovery in the life sciences

    Ronald D Vale, Anthony A Hyman
    Disclosing work prior to submission to a journal would benefit scientists seeking to be acknowledged for their discoveries.
  6. Racism in Science: We need to act now

    Michael B Eisen
    eLife, like the rest of science, must tackle the many inequalities experienced by Black scientists.
    Editorial
    Available as:
    • HTML
    • PDF
  7. Point of View: What’s in a name?

    Michael D Schaller et al.
    Standardizing the titles, terms and conditions under which postdocs are employed will benefit the biomedical research workforce.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.

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