1,023 results found
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins

    Xiaochuan Zhao et al.
    Combining in silico and experimental approaches to identify and understand the residue changes in the H-NS protein that allowed bacteria to adapt environment-sensing to different habitats.
    1. Microbiology and Infectious Disease

    Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

    Philip P Adams et al.
    Multiple RNA-seq approaches globally mapped RNA 3´ ends resulting in the discovery of numerous and diverse RNA regulators.
    1. Ecology

    A gustatory receptor tuned to the steroid plant hormone brassinolide in Plutella xylostella (Lepidoptera: Plutellidae)

    Ke Yang et al.
    The gustatory receptor PxylGr34 is tuned to the steroid plant hormone brassinolide and mediates the deterrent effects of brassinolide on feeding and ovipositing behaviors in Plutella xylostella.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies

    Manickam Gurusaran, Owen Richard Davies
    The LINC complex has a core 6:6 structure in which KASH-binding induces head-to-head interactions between SUN trimers, suggesting force transduction between cytoskeletal and nuclear components through branched LINC complex networks.
  1. Research Culture: A survey of early-career researchers in Australia

    Katherine Christian et al.
    Job insecurity is putting stress on early-career researchers in Australia, compromising their career development and potentially reducing the quality of research.
    1. Genetics and Genomics
    2. Neuroscience

    A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

    François Kroll et al.
    Zebrafish knockouts can be generated in a few hours directly from wild-type eggs and are suitable for studying continuous traits, including behaviour.
    1. Evolutionary Biology

    Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

    José Antonio Escudero et al.
    The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Therapeutic genetic variation revealed in diverse Hsp104 homologs

    Zachary M March et al.
    Exploring natural Hsp104 variation reveals unexpected tuning of a passive activity that inhibits aggregation of specific substrates to selectively counter TDP-43 or alpha-synuclein proteotoxicity connected to neurodegenerative disease.
    1. Cell Biology

    Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

    Chanjae Lee et al.
    DynAPs are liquid-like organelles that are partitioned into functional sub-domains.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

    Lakshmi E Miller-Vedam et al.
    Structure-function characterization of the EMC's cytoplasmic, transmembrane, and lumenal domains reveal features critical for terminal helix insertion and a specialized role for the lumenal domain in polytopic membrane protein biogenesis.

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