Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
Haiko Schurz, Vivek Naranbhai ... International Tuberculosis Host Genetics Consortium
Results from the largest tuberculosis genome-wide association study meta-analysis identified a significant association in the human leukocyte antigen class II region, rs28383206, across multiple populations.
Amanda M Hughes, Eleanor Sanderson ... Neil M Davies
It is unclear how much a child's BMI at age 8 affects their depressive and ADHD symptoms after family-level factors are accounted for, but a substantial impact on anxiety symptoms is unlikely.
Charles N Agoti, Lynette Isabella Ochola-Oyier ... George Githinji
Genomic analysis of initial SARS-CoV-2 waves in Kenya revealed Mombasa City as a key gateway for variants entering Coastal Kenya with onward inter-county transmission highlighting significance of surveillance in major cities for early warning of lineages entering local populations.
Miriam Romagosa, Sharon Nieukirk ... Mónica A Silva
The rapid and gradual fin whale songs changes adopted by individuals of a certain area provide evidence of vocal learning in this species, elucidate patterns of song evolution and hints on the limits of song variation.
A comprehensive genome scan of 18,000 multi-ethnic individuals with 3-dimensional facial images highlighted multiple face-associated genetic loci for which regulatory activities in human neural cells were established.
The findings have a major impact in understanding the different reward systems involved in two types of addictive behavior, and these advances have implications for prevention and treatment.
Simona Hankeova, Jakub Salplachta ... Emma Rachel Andersson
Dual resin casting of multiple lumenized systems followed by microCT allows visualization, digitalization, and quantification of architectural parameters defining the vascular and biliary systems in liver revealing new phenotypes.
Nosocomial transmission of SARS-Cov-2 in geriatric settings is complex, with different patterns between patients and healthcare workers working in Covid/non-Covid wards that should be taken into account when designing infection control strategies.
Eva M García-Cuesta, Pablo Martínez ... Mario Mellado
In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.