2,526 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial

    Lerato E Magosi, Yinfeng Zhang ... Marc Lipsitch
    HIV transmissions into intervention communities from control communities in the Botswana/Ya Tsie trial were similar to the reverse at baseline, and 10 times more common post-baseline, concordant with a predicted benefit of a universal test-and-treat HIV prevention intervention.
    1. Ecology
    2. Microbiology and Infectious Disease

    Universal gut microbial relationships in the gut microbiome of wild baboons

    Kimberly E Roche, Johannes R Bjork ... Elizabeth A Archie
    In baboon gut microbiota, most pairwise correlations in bacterial abundances are weak and negative, and bacterial correlation patterns are largely shared across hosts, rather than personalized to each hosts.
    1. Developmental Biology
    2. Physics of Living Systems

    On the origin of universal cell shape variability in confluent epithelial monolayers

    Souvik Sadhukhan, Saroj Kumar Nandi
    The nearly universal nature of scaled cell shape variability in an epithelial monolayer is unavoidable, irrespective of health or disease, as it comes from a mathematical property.
    1. Developmental Biology

    A universal reading network and its modulation by writing system and reading ability in French and Chinese children

    Xiaoxia Feng, Irene Altarelli ... Ghislaine Dehaene-Lambertz
    A cross-cultural study of reading acquisition and reading irmpairment reveals the invariance of the neural correlates of reading across cultures.
    1. Evolutionary Biology
    2. Neuroscience

    Neuro-evolutionary evidence for a universal fractal primate brain shape

    Yujiang Wang, Karoline Leiberg ... Bruno Mota
    Cortices from 11 primate species share the same archetypal fractal shape, indicating a universal mechanism for primate and mammalian cortical folding, and suggesting novel shape biomarkers for brains.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Universal and taxon-specific trends in protein sequences as a function of age

    Jennifer E James, Sara M Willis ... Joanna Masel
    Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
    1. Neuroscience

    A parameter-free statistical test for neuronal responsiveness

    Jorrit S Montijn, Koen Seignette ... J Alexander Heimel
    A simple and robust statistical test for neuronal stimulus response, that outperforms PSTH-based approaches such as t-tests and ANOVAs.
    1. Microbiology and Infectious Disease

    Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells

    Maria Eugenia Dieterle, Carles Solà-Riera ... Kartik Chandran
    Several previously proposed cell-surface receptors for hantaviruses could be deleted in endothelial cells with little or no effect on infection, indicating that critical hantavirus entry factors remain undiscovered.
    1. Evolutionary Biology

    An estimate of the deepest branches of the tree of life from ancient vertically evolving genes

    Edmund RR Moody, Tara A Mahendrarajah ... Tom A Williams
    Relatively few genes have evolved vertically from the last universal common ancestor to modern prokaryotes, and phylogenetic analysis of these genes demonstrates a great genetic distance between Archaea and Bacteria.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

    Catherine A Weibel, Andrew L Wheeler ... Joanna Masel
    Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.

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