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    1. Ecology
    2. Microbiology and Infectious Disease

    Endangered wild salmon infected by newly discovered viruses

    Gideon J Mordecai, Kristina M Miller ... Curtis A Suttle
    Newly discovered viruses in dead and dying farmed Chinook salmon are widely distributed in threatened wild Chinook and sockeye salmon populations.
    1. Physics of Living Systems

    Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

    Thomas C Day, Stephanie S Höhn ... Peter J Yunker
    The distributions of cellular neighborhood volumes in two very different multicellular species - snowflake yeast and Volvox carteri - are found to obey a common functional form arising from maximum entropy consideration, despite great differences in their cell division processes.
    1. Microbiology and Infectious Disease

    Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells

    Maria Eugenia Dieterle, Carles Solà-Riera ... Kartik Chandran
    Several previously proposed cell-surface receptors for hantaviruses could be deleted in endothelial cells with little or no effect on infection, indicating that critical hantavirus entry factors remain undiscovered.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A biophysical threshold for biofilm formation

    Jenna A Moore-Ott, Selena Chiu ... Sujit S Datta
    A biophysical model of the process by which bacteria transition from the motile planktonic state to the immobilized biofilm state yields testable predictions in terms of two dimensionless parameters, one describing nutrient availability and the other describing cellular dispersal.
    1. Computational and Systems Biology
    2. Neuroscience

    Meta-Research: Dataset decay and the problem of sequential analyses on open datasets

    William Hedley Thompson, Jessey Wright ... Russell A Poldrack
    Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.
    1. Evolutionary Biology

    Tradeoff breaking as a model of evolutionary transitions in individuality and limits of the fitness-decoupling metaphor

    Pierrick Bourrat, Guilhem Doulcier ... Katrin Hammerschmidt
    A new model describes evolutionary transitions in individuality in terms of tradeoff and tradeoff-breaking events as opposed to changes in the nature of fitness.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

    Emily Martyn, Sarah Eisen ... Philippa C Matthews
    Hepatitis B virus infection is a neglected challenge among communities who are under-served by conventional models of healthcare, requiring enhanced interventions to reduce inequity.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Population genomics of intrapatient HIV-1 evolution

    Fabio Zanini, Johanna Brodin ... Richard A Neher
    Whole genome deep sequencing of many longitudinally sampled HIV-1 populations reveals that reversions towards ancestral HIV-1 genome sequences occur throughout the course of infection.
    1. Immunology and Inflammation
    2. Medicine

    Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

    Erin J Ciampa, Padraich Flahardy ... Samir M Parikh
    The role of placental aging and metabolic stress in driving labor onset is demonstrated, with a novel mouse model of preterm labor in which injection of a prolyl hydroxylase inhibitor stabilizes placental hypoxia-inducible factor 1 and significantly shortens gestational length.
    1. Microbiology and Infectious Disease

    Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

    Lisanne de Vor, Bruce van Dijk ... Suzan HM Rooijakkers
    Antibody-based biologicals could provide an alternative approach to improve the diagnosis of Staphylococcus aureus biofilm-related infections.