2,660 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding

    Tristan A Bell et al.
    The AAA+ protein unfolding motor ClpX grips substrates with the uppermost part of its substrate-binding pore, and requires interactions with hydrophobic amino acid side chains to operate with optimal efficiency.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a AAA+ unfoldase in the process of unfolding substrate

    Zev A Ripstein et al.
    The structure of a substrate-engaged AAA+ unfoldase suggests a model for processive unfolding that is supported by biochemical data.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural evidence for Scc4-dependent localization of cohesin loading

    Stephen M Hinshaw et al.
    Cohesin loading at centromeres depends on a conserved surface cluster of amino-acid residues on the cohesin loading protein, Scc4.
    1. Plant Biology

    Phloem unloading in Arabidopsis roots is convective and regulated by the phloem-pole pericycle

    Timothy J Ross-Elliott et al.
    A study of solute and macromolecule trafficking in plants reveals a previously undescribed route for carbon distribution in growing root tissues.
    1. Cell Biology

    A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

    Ramiro Nández et al.
    Studies of Lowe syndrome patient cells, which lack the inositol 5-phosphatase OCRL, suggest that a defect in endocytosis plays a role in the pathological manifestations of the disease.
    1. Chromosomes and Gene Expression

    MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

    Ge Zheng et al.
    Systematic analyses of DNA replication machinery components in human cells reveal a requirement of MCM-dependent de novo loading or mobilization of cohesin at replication forks in establishing sister-chromatid cohesion.
    1. Structural Biology and Molecular Biophysics

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

    Thorsten G Müller et al.
    HIV-1 capsids enter the host cell nucleus, where they are partially disrupted to release the viral genome upon completion of reverse transcription.
    1. Biochemistry and Chemical Biology

    Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

    Julia R Kardon et al.
    The mitochondrial protein unfoldase ClpX activates the first enzyme in heme biosynthesis, ALAS, by targeted unfolding that gates access of cofactor to the ALAS active site.
    1. Structural Biology and Molecular Biophysics

    Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

    Lining Ju et al.
    New biophysical methods and analyses visualize in real-time a chain of coordinated single-molecular events on a living cell, enabling the inner workings of a mechanoreceptor important to biology to be elucidated.

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