255 results found
    1. Neuroscience

    DeepFly3D, a deep learning-based approach for 3D limb and appendage tracking in tethered, adult Drosophila

    Semih Günel et al.
    DeepFly3D, a deep learning-based software, measures limb and appendage movements in tethered, behaving Drosophila and enables precise behavioral measurements during neural recordings, stimulation, and other biological experiments.
    1. Computational and Systems Biology

    Meta-Research: International authorship and collaboration across bioRxiv preprints

    Richard J Abdill et al.
    An analysis of 67,885 preprints on bioRxiv finds evidence for disparities in international participation that are similar to the disparities found in conventional journals.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
  1. Point of View: A fair deal for PhD students and postdocs

    Henry R Bourne
    The relentless expansion that threatens the sustainability of biomedical research in the US takes a heavy toll on young researchers.
    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst et al.
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
    1. Neuroscience

    Retrieval practice facilitates memory updating by enhancing and differentiating medial prefrontal cortex representations

    Zhifang Ye et al.
    Retrieval practice strongly engages the medial prefrontal cortex to integrate and differentiate memory representations, resulting in more effective memory updating.
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates et al.
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

    Danyang Zhang et al.
    GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A single-parasite transcriptional atlas of Toxoplasma Gondii reveals novel control of antigen expression

    Yuan Xue et al.
    Single-cell RNA-sequencing resolves the transcriptional landscape of asexual development in Toxoplasma gondii, revealing concerted genetic programs to Plasmodiumfalciparum and a novel transcriptional factor that controls antigen switching.
    1. Structural Biology and Molecular Biophysics

    Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

    SeCheol Oh et al.
    Structures of the non-canonical potassium channel TMEM175 in open and closed states reveal unique mechanisms for channel gating and the selective permeation of K+ ions.

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