114 results found
    1. Cancer Biology

    The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

    Jacob T Polaski et al.
    UPF1 mutations were reportedly present at high frequencies in a cohort of pancreatic adenosquamous carcinoma patients, but these lesions are unlikely to be functional drivers of this cancer subtype.
    1. Chromosomes and Gene Expression

    The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

    Anand K Singh et al.
    UPF1 associates with nascent transcripts and plays a broad role in nuclear processes of gene expression.
    1. Chromosomes and Gene Expression

    Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants

    Lucas D Serdar et al.
    Nucleotide resolution mapping of ribosome-bound RNA decay fragments in yeast cells expressing ATPase-deficient UPF1 reveals 3' UTR bound ribosomes and a role for UPF1 in post-termination ribosome recycling.
    1. Cell Biology

    GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation

    Ming Li et al.
    GAS5 is related to osteoporosis by regulating the differentiation of bone marrow stromal cells that acts as a promising treatment target for osteoporosis.
    1. Genetics and Genomics

    PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock

    Christina M Kelliher et al.
    Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.
    1. Structural Biology and Molecular Biophysics

    Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

    Lukas M Langer et al.
    First structural view of a substrate-bound PIKK (PI3K-related-kinase) by cryo-EM explains phosphorylation specificity toward a short amino-acid motif shared across the PIKK family and rationalizes PIKK auto-inhibition by regulatory domain.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    The neuropeptide F/nitric oxide pathway is essential for shaping locomotor plasticity underlying locust phase transition

    Li Hou et al.
    Two neuropeptides, NPF1a and NPF2, act via the nitric oxide signaling pathway in the locust brain to regulate the trait transition between solitary and swarming behavior.
    1. Cell Biology
    2. Plant Biology

    Integration of two RAB5 groups during endosomal transport in plants

    Emi Ito et al.
    Plant-unique RAB5 effector 2 (PUF2) is an effector of plant-unique ARA6, which plays a key role in plant endosomal transport, integrating functions of the two plant RAB5 groups by an unprecedented mechanism.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

    Zhiyun Ge et al.
    The RNA-binding protein PTBP1 is recruited to sites near stop codons in retroviral and human mRNAs, shielding them from detection and degradation by the nonsense-mediated mRNA decay pathway.
    1. Genetics and Genomics

    A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy

    Qing Feng et al.
    Expression of the disease gene DUX4 inhibits RNA quality control in skeletal muscle, thereby stabilizing thousands of aberrant RNAs, including its own transcript.

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