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Viewing the dynamic interactions of individual spliceosomal subcomplexes with single pre-messenger RNA molecules reveals how nearby flanking splice sites accelerate pre-spliceosome assembly and the splicing of multi-intron pre-mRNAs.

BisMapR reveals strand-specific R-loops with high resolution at small-scale genomic features including bidirectionally transcribed promoters and enhancers.

Mapping of 30 general RNA degradation factors onto the yeast transcriptome provides the global distribution of factors for RNA turnover and surveillance in a eukaryotic cell.

Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.

PHAROH lncRNA is upregulated in hepatocellular carcinoma and functions by sequestering the translational suppressor TIAR via a 71 nucleotide hairpin to regulate c-MYC translation.

Disruption of the nucleosome DNA entry-exit site causes readthrough transcription of terminators, decreased nucleosome occupancy, and pervasive noncoding transcription, demonstrating this nucleosomal region protects the genome against inappropriate transcription.

Genetic and bioinformatic analyses uncover an unexpected role for codon usage biases in regulating gene expression at the transcriptional level by suppressing premature transcription termination.

Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.

Bidirectional promoter activity, which is inherent to the promoters of selection cassettes used for genome editing, causes divergent transcription that can disrupt expression of genes neighboring cassette insertion sites, causing potent off-target effects.

Sequences at mitochondrial genome recombination sites are dually used as mRNAs and as rRNAs in actively translating mitoribosomes of T. gondii.