The use of liquid-infused catheters results in significant reduction of bladder and catheter colonization, systemic dissemination, and bladder inflammation in a clinically relevant mouse model of CAUTI by targeting host-protein deposition on the urinary catheter.

A new combined approach using X-ray fluoroscopy and machine learning provides detailed new insights into bladder function in awake, unrestrained mice and unveils important limitations of current approaches to study bladder function.

Targeting the interaction between the kidneys and brain may increase the efficiency of SGLT2 inhibitors to better manage type 2 diabetes.

Ampakines demonstrate efficacy in enhancing bladder function in animal models of spinal cord injury, presenting promising prospects for innovative pharmacotherapy to alleviate post-injury bladder dysfunction.

Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.

Ponto-spinal CRH neurons in Barrington’s nucleus are a core component of an inferential circuit that regulates autonomous micturition and generates voids when the bladder is full.

Single-nuclear transcriptomic profiling and functional assays identified PKR activation and mitochondrial dysfunction in HIV-associated nephropathy mice kidneys.

Trimethylamine-oxide (TMAO), a molecule present in seafood, reduces mortality and exerts beneficial effects on the circulatory system in heart failure rats.

Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.