Identification and functional characterization of C. elegans luqin-like arginine-tyrosine-NH2 (RYamide) peptides reveal their critical role in feeding-related processes.
Elizabeth A Williams, Csaba Verasztó ... Gáspár Jékely
A combination of electron microscopic reconstruction and the analysis of single cell transcriptome data is used to reconstruct synaptic and peptidergic signaling networks in a neurosecretory centre.
Two critical events initiate and promote efficient desmosome assembly: stable binding of opposing E-cadherin cell-cell adhesion proteins; and direct interaction of E-cadherin and Desmoglein.
Jessica J Stanisich, Dawid S Zyla ... Rudi Glockshuber
Cryo-EM reveals that an unexpected domain separation in the zona pellucida module of uromodulin is required for its assembly to filamentous homopolymers that promote pathogen clearance in urinary tract infections.
Spontaneous elongation of epithelial colonies is related to the orientation of the mean nematic cell elongation field, as shown and tested with experiments and theory.
Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.