12 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

    Martina Brunati, Simone Perucca ... Luca Rampoldi
    Hepsin is the first protease identified to modulate specific cleavage and secretion of a Zona Pellucida domain protein, uromodulin.
    1. Computational and Systems Biology
    2. Neuroscience

    Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

    Daniel Kueh, William H Barnett ... Ronald L Calabrese
    The dynamic current generated Na+/K+ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.
    1. Cancer Biology

    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

    Alessia Calcagnì, Lotte kors ... Andrea Ballabio
    Kidney-specific TFEB overexpression in transgenic mice closely recapitulates features observed in both TFEB- and TFE3-mediated human kidney tumors.
    1. Neuroscience

    Luqin-like RYamide peptides regulate food-evoked responses in C. elegans

    Hayao Ohno, Morikatsu Yoshida ... Yuichi Iino
    Identification and functional characterization of C. elegans luqin-like arginine-tyrosine-NH2 (RYamide) peptides reveal their critical role in feeding-related processes.
    1. Neuroscience

    Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain

    Elizabeth A Williams, Csaba Verasztó ... Gáspár Jékely
    A combination of electron microscopic reconstruction and the analysis of single cell transcriptome data is used to reconstruct synaptic and peptidergic signaling networks in a neurosecretory centre.
    1. Cell Biology

    Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

    Masako Okumura, Toyoaki Natsume ... Tomomi Kiyomitsu
    Optogenetic reconstitution reveals core functional modules and architecture of the cortical force-generating machinery in human cells.
    1. Cell Biology

    E-cadherin binds to desmoglein to facilitate desmosome assembly

    Omer Shafraz, Matthias Rübsam ... Sanjeevi Sivasankar
    Two critical events initiate and promote efficient desmosome assembly: stable binding of opposing E-cadherin cell-cell adhesion proteins; and direct interaction of E-cadherin and Desmoglein.
    1. Structural Biology and Molecular Biophysics

    The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

    Jessica J Stanisich, Dawid S Zyla ... Rudi Glockshuber
    Cryo-EM reveals that an unexpected domain separation in the zona pellucida module of uromodulin is required for its assembly to filamentous homopolymers that promote pathogen clearance in urinary tract infections.
    1. Physics of Living Systems

    Epithelial colonies in vitro elongate through collective effects

    Jordi Comelles, Soumya SS ... Daniel Riveline
    Spontaneous elongation of epithelial colonies is related to the orientation of the mean nematic cell elongation field, as shown and tested with experiments and theory.
    1. Cell Biology
    2. Developmental Biology

    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

    Eric T Hall, Miriam E Dillard ... Stacey K Ogden
    Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.

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